Maternal MDMA administration in mice leads to neonatal growth delay

Access this Article

Author(s)

    • Kaizaki Asuka Kaizaki Asuka
    • Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy
    • Numazawa Satoshi
    • Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy

Abstract

The psychoactive recreational drug 3,4-methylenedioxymethamphetamine (MDMA) is widely abused. The fact that MDMA induces neurotoxic damage in serotonergic nerve endings is well known. However, the effects of MDMA on pregnant and neonatal animals remain unknown. Therefore, we studied the effects of gestational exposure to MDMA on birth, growth, and behavior of pups. Female BALB/c mice were orally administered either water (10 ml/kg) or MDMA (20 mg/10 ml/kg) from gestational day 1 to postnatal day (P) 21. MDMA did not affect the birth rate, but the survival rate of the pups significantly decreased. A significant reduction in body weight gain was observed in pups from MDMA-administered dams during P3-P21. Maternal MDMA treatment caused an attenuated cliff avoidance reaction and decreased motor function in the pups, as determined by the wire hanging test. These results suggest that MDMA treatment during pregnancy and lactation causes growth retardation and dysfunction of motor neurons in mouse pups.

Journal

  • The Journal of Toxicological Sciences

    The Journal of Toxicological Sciences 39(1), 33-39, 2014

    The Japanese Society of Toxicology

Codes

  • NII Article ID (NAID)
    130004447112
  • NII NACSIS-CAT ID (NCID)
    AN00002808
  • Text Lang
    ENG
  • ISSN
    0388-1350
  • NDL Article ID
    025244014
  • NDL Call No.
    Z19-1022
  • Data Source
    NDL  J-STAGE 
Page Top