Associations Between <i>hOGG1</i> Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population

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Author(s)

    • Hara Megumi
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • Mantjoro Eva Mariane
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science
    • Ohnaka Keizo
    • Department of Geriatric Medicine, Kyushu University Graduate School of Medical Sciences
    • Uemura Hirokazu
    • Department of Preventive Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
    • Matsui Daisuke
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
    • Oze Isao
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • Mikami Haruo
    • Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center
    • Kubo Michiaki
    • Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN
    • Tanaka Hideo
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • Nishida Yuichiro
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • Hishida Asahi
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • Kawai Sayo
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • Hamajima Nobuyuki
    • Department of Healthcare Administration, Nagoya University Graduate School of Medicine
    • Kita Yoshikuni
    • Department of Health Science, Shiga University of Medical Science
    • Suzuki Sadao
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences

Abstract

<b>Background: </b>Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (<i>hOGG1</i>), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the <i>hOGG1</i> genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the <i>hOGG1</i> genotype and body mass index (BMI) and fasting blood glucose (FBG) levels.<BR><b>Methods: </b>Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40–69 years. The <i>hOGG1</i> polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables.<BR><b>Results: </b>The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (>27.5 kg/m<sup>2</sup>). However, the impact of genotype decreased and significance disappeared after adjusting for the study area.<BR><b>Conclusions: </b>The present results suggest that the study area being inside Japan confounds the association between <i>hOGG1</i> genotype and obesity.

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 24(5), 379-384, 2014

    Japan Epidemiological Association

Codes

  • NII Article ID (NAID)
    130004449419
  • Text Lang
    ENG
  • ISSN
    0917-5040
  • Data Source
    J-STAGE 
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