Behavioral Resistance of <i>Caenorhabditis elegans</i> Against High-LET Radiation Exposure

• Sakashita Tetsuya

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Suzuki Michiyo

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Hamada Nobuyuki

  Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI)

• Shimozawa Yoko

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Shirai-Fukamoto Kana

  Laboratory of Silkworm Physiology, Faculty of Textile Science and Technology, Shinshu University

• Yokota Yuichiro

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Hamada-Sora Sakura

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Kakizaki Takehiko

  Department of Veterinary Medicine, Kitasato University Graduate School of Veterinary Medicine and Animal Sciences

• Wada Seiichi

  Department of Veterinary Medicine, Kitasato University Graduate School of Veterinary Medicine and Animal Sciences

• Funayama Tomoo

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Kobayashi Yasuhiko

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

Bibliographic Information

Other Title

• Behavioral Resistance of Caenorhabditis elegans Against High-LET Radiation Exposure

Abstract

Effects of high linear energy transfer (LET) radiation on the functions of the nervous system is a potential risk in interplanetary manned space missions. However, little is known about how the nervous system is protected against high-LET radiation exposure. The analysis of high-LET radiation resistant animals would be therefore important for space missions. Here, we investigated the resistance to high-LET radiation exposure for two behaviors of the nematode, Caenorhabditis elegans, which is known as a model organism for the nervous system. Tested behaviors were locomotion and chemotaxis to NaCl. In addition, egg hatchability was examined as an indicator of high-LET radiation sensitivity. Relative biological effectiveness (RBE) of high-LET radiation (¹²C, 18.3 MeV/u, LET = 113 keV/μm) relative to low-LET radiation for hatchability was 4.5, whereas RBEs for locomotion and chemotaxis were 1.4 and 1.1, respectively. This study shows that the behavioral system for locomotion and chemotaxis of C. elegans is highly resistant to high-LET radiation exposure.

Journal

• Biological Sciences in Space

  Biological Sciences in Space 26 (0), 7-11, 2012

  Japanese Society for Biological Sciences in Space

Keywords

• General Medicine

Details

• CRID: 1390001204432193536
• NII Article ID: 130004450620
• DOI: 10.2187/bss.26.7
• ISSN: 1349967X
• ISSN: 09149201
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed