Effects of Low- and High-LET Radiation on the Salt Chemotaxis Learning in Caenorhabditis elegans

• Sakashita Tetsuya

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Suzuki Michiyo

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Hamada Nobuyuki

  Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI)

• Shimozawa Yoko

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Shirai-Fukamoto Kana

  Laboratory of Silkworm Physiology, Faculty of Textile Science and Technology, Shinshu University

• Yokota Yuichiro

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Hamada-Sora Sakura

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Kakizaki Takehiko

  Department of Veterinary Medicine, Kitasato University Graduate School of Veterinary Medicine and Animal Sciences

• Wada Seiichi

  Department of Veterinary Medicine, Kitasato University Graduate School of Veterinary Medicine and Animal Sciences

• Funayama Tomoo

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

• Kobayashi Yasuhiko

  Microbeam Radiation Biology Group, Japan Atomic Energy Agency (JAEA)

書誌事項

タイトル別名

• Effects of Low- and High-LET Radiation on the Salt Chemotaxis Learning in <i>Caenorhabditis elegans</i>

抄録

High linear energy transfer (LET) radiation is important components of cosmic rays that has neurobiological effects: it is known to induce conditioned taste aversion, and suppress neurogenesis that may underlie cognitive impairment. However, the impact of high-LET radiation on other learning effects remains largely unknown. Here, we focus on kinetics of the radiation response for the salt chemotaxis learning (SCL) behavior in the nameatode, Caenorhabditis elegans, because the SCL during the learning conditioning was modulated after low-LET γ-irradiation. Firstly, the SCL ability was examined following high-LET irradiation (¹²C, 18.3 MeV/u, LET = 113 keV/μm), revealing its dose-dependent decrease after high- and low-LET exposure. Next, we demonstrate that the SCL at the early phase of the learning conditioning is greatly affected by high- and low-LET irradiation, and interestingly, the magnitude of these effects by high-LET radiation was significantly smaller than that by low-LET one. Moreover, the analysis of gpc-1 mutant showed that the G-protein γ subunit, GPC-1 is responsible for such early phase response. This study is the first to provide the evidence for the kinetics of changes in SCL after high-LET irradiation of C. elegans.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ　ｉｎ　Ｓｐａｃｅ

  Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ　ｉｎ　Ｓｐａｃｅ 26 (0), 21-25, 2012

  日本宇宙生物科学会

キーワード

• General Medicine

詳細情報

• CRID: 1390001204431981696
• NII論文ID: 130004450622
• DOI: 10.2187/bss.26.21
• ISSN: 1349967X
• ISSN: 09149201
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可