Evaluation of a 3-D, Woven-fabric, Composite Scaffold Using Experimental Canine Models of Bone Defects in Mandibles

Access this Article

Author(s)

    • BABA Shunsuke
    • Department of Regenerative Medicine, Foundation for Biomedical Research and Innovation
    • ADACHI Taiji
    • Department of Biomechanics, Research Center for Nano Medical Engineering Institute for Frontier in Medical Sciences, Kyoto University
    • INOUE Takeomi
    • Department of Regenerative Medicine, Foundation for Biomedical Research and Innovation
    • SONODA Yumi
    • Department of Orthodontics, Osaka Dental University
    • YAMADA Yoichi
    • Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
    • ITO Kenji
    • Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
    • HOJO Masaki
    • Department of Mechanical Engineering and Science, Kyoto University

Abstract

A woven-fabric scaffold, composed of biodegradable poly-L-lactic acid resin fibers and injected with marrow-derived mesenchymal cells mixed with platelet-rich plasma, was developed to evaluate the <i>in vivo</i> performance of a cell-scaffold graft material in experimental bone defects created in the dog mandible. Defects of regular shape and significant size were created at furcation sites and on the mesial aspects of lower premolar roots and then treated with graft material and subjected to histological analysis after 4 and 8 weeks of healing. In the experimental group, bone regeneration in defects on the tooth root mesial aspect occurred at 8 weeks, accompanied by the regeneration of periodontal tissues, such as cementum and periodontal ligaments. In contrast, delayed and immature healing was observed in the control group defects with no graft material. The findings here indicated that a three-dimensional, woven-fabric, composite scaffold combined with mesenchymal cells and platelet-rich plasma could accelerate the regeneration of alveolar bone and periodontal tissues.

Journal

  • Journal of Oral Tissue Engineering

    Journal of Oral Tissue Engineering 8(3), 212-221, 2011

    Japanese Association of Regenerative Dentistry

Codes

  • NII Article ID (NAID)
    130004456623
  • Text Lang
    ENG
  • ISSN
    1348-9623
  • Data Source
    J-STAGE 
Page Top