Medicinal Aspects of Vanadium Complexes: Treatment of Diabetes Mellitus in Model Animals

• Sakurai Hiromu

  Department of Analytical and Bioinorganic Chemistry Kyoto Pharmaceutical University

抄録

An overview is presented of vanadium-based insulinomimetic and anti-diabetic complexes aiming at the development of clinically useful anti-diabetic medicines as replacements of daily insulin injections for type 1 diabetes and synthetic antidiabetic drugs. After described on the advantage for the use of vanadyl ion (oxovanadium(IV), +4 oxidation state of vanadium, VO²⁺) in terms of toxicity in animals and bio-state of the metal ion, recent progress on the development of antidiabetic vanadyl complexes proposed in our research group is reviewed with emphasis of the importance of the study on structure-activity relationship for vanadyl-picolinate complexes to find more active complexes than the leading compound and of the development of new drug delivery system either the enteric-coated capsule containing simple vanadyl sulfate or the use of a biopolymer, poly(γ-glutamic) acid, bound with vanadyl sulfate. The challenges for future research are also described.

収録刊行物

• Biomedical Research on Trace Elements

  Biomedical Research on Trace Elements 18 (3), 241-248, 2006

  日本微量元素学会

キーワード

• diabetes
• hypoglycemic effect
• vanadyl complex
• structure-activity relationship
• coordination environment
• drug delivery system (DDS)

詳細情報

• CRID: 1390282679342344320
• NII論文ID: 130004456838
• DOI: 10.11299/brte.18.241
• ISSN: 18801404
• ISSN: 0916717X
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可