Efficacy of Tonsillectomy Plus Methylprednisolone Pulse Therapy for a Child with Henoch-Schoenlein Purpura Nephritis

DOI Web Site 被引用文献6件 参考文献23件
  • Kawasaki Yukihiko
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Suyama Kazuhide
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Matsumoto Ayumi
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Takano Kei
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Hashimoto Koichi
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Suzuki Sigeo
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Suzuki Junzo
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Suzuki Hitoshi
    Department of Pediatrics, Fukushima Medical University School of Medicine
  • Hosoya Mitsuaki
    Department of Pediatrics, Fukushima Medical University School of Medicine

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Henoch-Schoenlein purpura (HSP) is a systemic disorder characterized by a leukocytoplastic vasculitis involving small vessels with the deposition of immunoglobulin A (IgA) immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. We report here an 11-year-old boy with Henoch-Schoenlein purpura nephritis (HSPN) accompanied by recurrent purpura and persistent nephropathy despite conventional therapy such as prednisolone, methylprednisolone pulse therapy and immunosuppressive agent (Mizoribine). The patient was treated with tonsillectomy plus methylprednisolone pulse therapy. This treatment decreased proteinuria, induced disappearance of microscopic hematuria, and improved renal pathological findings. Tonsillectomy plus methylprednisolone pulse is effective and useful therapy for some children with recurrent purpura and persistent nephropathy.

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