Effect of Genetic Polymorphism of OATP-C (SLCO1B1) on Lipid-Lowering Response to HMG-CoA Reductase Inhibitors

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Author(s)

    • MIKI Tetsuro
    • Department of Geriatric Medicine, Ehime University School of Medicine
    • TABARA Yasuharu
    • Department of Medical Genetics, Ehime University School of Medicine
    • KUSUHARA Hiroyuki
    • Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
    • NAKURA Jun
    • Department of Geriatric Medicine, Ehime University School of Medicine
    • TOKUNAGA Katsushi
    • Department of Human Genetics, Graduate School of Medicine, The University of Tokyo
    • KONDO Ikuko
    • Department of Medical Genetics, Ehime University School of Medicine
    • SUGIYAMA Yuichi
    • Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Abstract

  The effect of genetic polymorphism of human organic anion transporting polypeptide C (OATP-C) on the lipid-lowering response to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors was assessed.<br>    A retrospective study was conducted on 66 patients who underwent treatment of hyperlipidemia with HMG-CoA reductase inhibitors in a municipal hospital in a community-based cohort of Ehime prefecture in the southern part of Japan. Plasma lipid concentrations before and after administration were analyzed in patients in relation to the 521T/C (Val-174→Ala) polymorphism in the OATP-C gene (TT: n=44 (66.7%), TC: n=20 (30.3%), CC: n=0 (0.0%), undetermined: n=2 (3.0%)). Total cholesterol level was significantly lowered after treatment with HMG-CoA reductase inhibitors in all patients (p<0.001); moreover, subjects with the 521C allele showed an attenuated total-cholesterol-lowering effect compared with those homozygous for the 521T allele (-22.3±8.7% vs. -16.5±10.5%, p<0.05).<br>    These data suggest that the 521T/C polymorphism of the OATP-C gene modulates the lipid-lowering efficacy of HMG-CoA reductase inhibitors.<br>

Journal

  • Drug Metabolism and Pharmacokinetics

    Drug Metabolism and Pharmacokinetics 19(5), 375-380, 2004

    The Japanese Society for the Study of Xenobiotics

Codes

  • NII Article ID (NAID)
    130004462945
  • Text Lang
    ENG
  • ISSN
    1347-4367
  • Data Source
    J-STAGE 
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