Absence of Influence of Concomitant Administration of Rabeprazole on the Pharmacokinetics of Tacrolimus in Adult Living-donor Liver Transplant Patients: A Case-Control Study
-
- HOSOHATA Keiko
- Department of Pharmacy, Kyoto University Hospital
-
- MASUDA Satohiro
- Department of Pharmacy, Kyoto University Hospital
-
- YONEZAWA Atsushi
- Department of Pharmacy, Kyoto University Hospital
-
- SUGIMOTO Mitsuhiro
- Department of Pharmacy, Kyoto University Hospital
-
- TAKADA Yasutsugu
- Department of Surgery, Graduate School of Medicine, Kyoto University
-
- KAIDO Toshimi
- Department of Surgery, Graduate School of Medicine, Kyoto University
-
- OGURA Yasuhiro
- Department of Surgery, Graduate School of Medicine, Kyoto University
-
- OIKE Fumitaka
- Department of Surgery, Graduate School of Medicine, Kyoto University
-
- UEMOTO Shinji
- Department of Surgery, Graduate School of Medicine, Kyoto University
-
- INUI Ken-ichi
- Department of Pharmacy, Kyoto University Hospital
この論文をさがす
抄録
This study assesses the effects of rabeprazole on the pharmacokinetics of tacrolimus, considering the cytochrome P450 (CYP) 2C19 and CYP3A5 genotypes of living-donor liver transplant patients (native intestine) and their corresponding donors (graft liver). We examined the concentration/dose ratio of tacrolimus in transplant patients treated with (n=17) or without (n=38) rabeprazole at 10 mg/day on postoperative days 22-28. A stratified analysis revealed no significant differences between the control and rabeprazole groups in the median (range) concentration/dose ratio of tacrolimus [(ng/mL)/(mg/day)] for CYP2C19 extensive/intermediate metabolizers [2.71 (1.00-6.15) versus 2.55 (0.96-9.25); P=0.85] and for poor metabolizers [4.92 (2.44-7.00) versus 3.82 (2.00-7.31); P=0.68], respectively. Even based on the classification of CYP2C19 genotypes of donors, no significant difference in the concentration/dose ratio of tacrolimus was found for the two groups (CYP2C19 extensive/intermediate metabolizers, P=0.52; poor metabolizers, P=0.51). The same was observed for CYP3A5*1 carriers (P=0.97 for native intestine; P=0.87 for graft liver) and CYP3A5*3/*3 carriers (P=0.89 for native intestine; P=0.56 for graft liver). These findings suggest a safer dosing and monitoring of tacrolimus coadministered with rabeprazole early on after liver transplantation regardless of the CYP2C19 and CYP3A5 genotypes of transplant patients and their donors.<br>
収録刊行物
-
- Drug Metabolism and Pharmacokinetics
-
Drug Metabolism and Pharmacokinetics 24 (5), 458-463, 2009
日本薬物動態学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205180075648
-
- NII論文ID
- 130004463096
- 10025724750
-
- NII書誌ID
- AA1162652X
-
- COI
- 1:CAS:528:DC%2BD1MXhs1WhtrfP
-
- ISSN
- 18800920
- 13474367
-
- PubMed
- 19881258
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可