Frequency of the Functionally Relevant Aryl Hydrocarbon Receptor Repressor (AhRR) Pro185Ala SNP in Papua New Guinea
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- CAVACO Isa
- Institute of Biotechnology and Bioengineering, Center of Molecular and Structural Biomedicine, University of Algarve Drug Resistance Unit, Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet
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- HOMBHANJE Francis Wanak
- Centre for Health Research, Divine Word University
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- GIL José Pedro
- Institute of Biotechnology and Bioengineering, Center of Molecular and Structural Biomedicine, University of Algarve Drug Resistance Unit, Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet Department of Biological Sciences, The Harpur College of Arts and Sciences, Binghamton University
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- KANEKO Akira
- Island Malaria Group, Department of Microbioloy, Tumour and Cell Biology, Karolinska Institutet Department of Parasitology, Osaka City University Graduate School of Medicine Institute of Tropical Medicine (NEKKEN), Nagasaki University
書誌事項
- タイトル別名
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- Frequency of the Functionally Relevant Aryl Hydrocarbon Receptor Repressor (<i>AhRR</i>) Pro185Ala SNP in Papua New Guinea
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The diverse cultural and social habits of the Papua New Guinea (PNG) population include betel quid chewing and more recently smoking. The formation of DNA adducts from betel quid is mediated by the cytochrome P450 (CYP) enzymes, including CYP1A2. The tobacco smoke compounds can induce CYP1A2. The transcription factor AhR (aryl hydrocarbon receptor) is involved in the regulation of CYP1A2 expression. AhR activity is itself regulated by other transcription factors, including the aryl hydrocarbon receptor repressor (AhRR). The AhRR Pro185Ala (rs2292596; 565C>G) minor allele was recently associated with a lower AhR repressor activity, leading to a higher CYP1A2 inducibility. We investigated AhRR Pro185Ala SNP in the East Sepik populations in PNG and found a high frequency of 53.4% of the minor allele, significantly different from other Asian populations. We can hypothesize that a high frequency of the AhRR SNP can be a risk factor in the incidence of oral cancer and other neoplasias in PNG due to higher inducibility of CYP1A2. The potential role of AhRR pharmacogenetics in the risk of developing cancers associated with betel quid chewing and smoking should be addressed and clarified in future epidemiological studies in PNG.<br>
収録刊行物
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- Ｄｒｕｇ Ｍｅｔａｂｏｌｉｓｍ ａｎｄ Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ
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Ｄｒｕｇ Ｍｅｔａｂｏｌｉｓｍ ａｎｄ Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ 28 (6), 519-521, 2013
日本薬物動態学会