Living-donor liver transplantation: present status and future perspective

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  • Shimada Mitsuo
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Fujii Masahiko
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Morine Yuji
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Imura Satoru
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Ikemoto Tetsuya
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Ishibashi Hiroki
    Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School

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About 15 years have passed since the first liver transplant from a living donor (living donor liver transplantation: LDLT), and the status of the procedure has since been established as a standard cure for end-stage liver disease in Japan where liver transplantation (LTx) from deceased donors has not yet been accepted. However, the following problems are surfacing with the increase in the number of LDLTs between adults: graft size mismatching, an ABO blood-type incompatible transplantation, the expansion of LDLT indication to hepatocellular carcinoma (HCC), the relapse of hepatitis C after LDLT, marginal donors, and the freedom from immunosuppressive treatment. In this article we outline the present conditions of these problems and the future view of the LDLT. J. Med. Invest. 52: 22-32, February, 2005

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