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- Sakai Tohru
- Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School
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- Kogiso Mari
- Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School
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抄録
The amount of soy products consumed in Japan is much greater than that in Western countries. Recent evidence indicates that soy isoflavones play a beneficial role in obesity, cancer, osteoporosis, and cardiovascular disease. The soybean isoflavone genistein is present at high levels in soy products. Genistein is structurally similar to 17β-estradiol (E2), and genistein has been suggested to be act as E2 or an antagonist against E2. Genistein suppresses antigen-specific immune response in vivo and lymphocyte proliferation response in vitro. However, genistein enhances the cytotoxic response mediated by NK and cytotoxic T cells and the cytokine production from T cells. Thus, the effect of genistein on immunity is immune cell-dependent. Due to its unique effect on immune function, genistein has been used for the treatment of the diseases in animal models and it has been found that genistein inhibits allergic inflammatory responses. In this review, we summarize current studies related to the effect of isoflavone genistein on the immune system. J. Med. Invest. 55: 167-173, August, 2008
収録刊行物
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 55 (3,4), 167-173, 2008
国立大学法人 徳島大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390282679221658880
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- NII論文ID
- 130004465138
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- NII書誌ID
- AA11166929
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- ISSN
- 13496867
- 13431420
- http://id.crossref.org/issn/13431420
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可