Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis

• Sata Masataka

  Department of Cardiovascular Medicine, Institute of Health Bioscience, the University of Tokushima Graduate School

• Fukuda Daiju

  Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

Abstract

The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy. J. Med. Invest. 57: 12-25, February, 2010

Journal

• The Journal of Medical Investigation

  The Journal of Medical Investigation 57 (1,2), 12-25, 2010

  The University of Tokushima Faculty of Medicine

Keywords

• atherosclerosis
• renin-angiotensin system
• reactive oxygen species
• inflammation

Details

• CRID: 1390282679220146304
• NII Article ID: 130004465188
• NII Article ID: 80020865947
• NII Book ID: AA11166929
• DOI: 10.2152/jmi.57.12
• ISSN: 13496867
• ISSN: 13431420
• ISSN: http://id.crossref.org/issn/13431420
• Web Site: http://repo.lib.tokushima-u.ac.jp/66339
• Web Site: http://www.jstage.jst.go.jp/article/jmi/57/1,2/57_1,2_12/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010325333
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed