Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice

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Author(s)

    • Teshigawara Kiyoshi
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Biofunctional Evaluation Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama
    • Sakai Tohru
    • Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Nakaya Yutaka
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Hosaka Toshio
    • Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Yamaguchi Miwa
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Terada Eri
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • kisyuku Yuka
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Fukunaga Keiko
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Hirata Yohko
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Jambaldorj Bayasgalan
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
    • Harada Nagakatsu
    • Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School

Abstract

Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus. J. Med. Invest. 57: 224-231, August, 2010

Journal

  • The Journal of Medical Investigation

    The Journal of Medical Investigation 57(3,4), 224-231, 2010

    The University of Tokushima Faculty of Medicine

Codes

  • NII Article ID (NAID)
    130004465212
  • Text Lang
    ENG
  • ISSN
    1343-1420
  • DOI
    10.2152/jmi.57.224
  • Data Source
    J-STAGE 
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