Growth ability in various macaque cell lines of HIV-1 with simian cell-tropism
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- Doi Naoya
- Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Fujiwara Sachi
- Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Adachi Akio
- Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
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- Nomaguchi Masako
- Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
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Abstract
We have recently constructed a series of novel human immunodeficiency viruses (HIV-1s) that are tropic for a macaque cell line (mt; macaque cell-tropic) to generate and establish a primate experimental system for HIV-1/AIDS study. In order to determine biological properties of these viruses effectively, several other macaque cell lines with distinct characteristics that can be routinely and easily used, instead of primary cells, for infection experiments are required. In this study, we have examined four macaque cell lines for their surface expression of virus receptor molecules and for their genotype of a major anti-viral capsid gene. Furthermore, we monitored the susceptibility of the cell lines to a standard simian immunodeficiency virus (SIV) clone and three representative basic mt HIV-1 clones. Results obtained here have clearly indicated that these cell lines are exquisitely useful to characterize various SIVs and more importantly, mt HIV-1s. J. Med. Invest. 57: 284-292, August, 2010
Journal
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 57 (3,4), 284-292, 2010
The University of Tokushima Faculty of Medicine
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Details 詳細情報について
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- CRID
- 1390001204244061056
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- NII Article ID
- 130004465220
- 80021262347
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- NII Book ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed