Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine

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Author(s)

    • Shimabukuro Michio
    • Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
    • Yamakawa Ken
    • Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital
    • Higa Moritake
    • Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital
    • Soeki Takeshi
    • Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
    • Masuzaki Hiroaki
    • Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
    • Sata Masataka
    • Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
    • Kozuka Chisayo
    • Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
    • Taira Shin-ichiro
    • Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
    • Yabiku Koichi
    • Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology, Second Department of Internal Medicine, University of the Ryukyus School of Medicine Graduate School of Medicine
    • Ishida Masayoshi
    • Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
    • Matsumoto Sachiko
    • Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
    • Yagi Shusuke
    • Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
    • Fukuda Daiju
    • Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences|Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences

Abstract

The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD) and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account that visceral fat plays an essential role in the development of metabolic and cardiovascular diseases. However, MetS cannot be used to assess global CVD risk but is at best one more modifiable CVD risk factor. Thus, global cardiometabolic risk (the global risk of cardiovascular disease resulting from traditional risk factors combined with the additional contribution of the metabolic syndrome and/or insulin resistance) should be considered individually. There is solid evidence supporting the notion that excess abdominal fat is predictive of insulin resistance and the presence of related metabolic abnormalities currently referred to as MetS. Despite the fact that abdominal obesity is a highly prevalent feature of MetS, the mechanisms by which abdominal obesity is causally related to MetS are not fully elucidated. Besides visceral fat accumulation, ectopic lipid deposition, especially in liver and skeletal muscle, has been implicated in the pathophysiology of diabetes, insulin resistance and obesity-related disorders. Also, ectopic fat deposition could be deteriorated in the heart components such as (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat. In this review, the contribution of ectopic lipid deposition to global cardiometabolic risk is reviewed and also discussed are potential underlying mechanisms including adipocytokine, insulin resistance and lipotoxicity. J. Med. Invest. 60: 1-14, February, 2013

Journal

  • The Journal of Medical Investigation

    The Journal of Medical Investigation 60(1.2), 1-14, 2013

    The University of Tokushima Faculty of Medicine

Codes

  • NII Article ID (NAID)
    130004465276
  • Text Lang
    ENG
  • ISSN
    1343-1420
  • Data Source
    J-STAGE 
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