Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats

• Ndong Moussa

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Uehara Mariko

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Katsumata Shin-ichi

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Suzuki Kazuharu

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

抄録

Medicinal plants constitute an important source of potential therapeutic agents for diabetes. In the present study, we investigated the effects of Moringa oleifera (MO) Lam, Moringacea, on glucose tolerance in Wistar rats and Goto-Kakizaki (GK) rats, modeled type 2 diabetes. Major polyphenols in MO powder were quercetin glucosides, rutin, kaempferol glycosides and chlorogenic acids by HPLC analysis. As the results of glucose tolerance test, MO significantly decreased the blood glucose at 20, 30, 45and 60 min for GK rats and at 10, 30 and 45 min for Wistar rats (p<0.05) compared to the both controls after glucose administration. The area under the curve of changes in the blood glucose was significantly higher in the GK control group than in the GK plus MO group (p<0.05) in the periods 30-60 min and 60-120 min. Furthermore, MO significantly decreased stomach emptying in GK rats (p<0.05). The results indicated that MO has an ameliorating effect for glucose intolerance, and the effect might be mediated by quercetin-3-glucoside and fiber contents in MO leaf powder. The action of MO was greater in GK rats than in Wistar rats.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 40 (3), 229-233, 2007

  一般社団法人　日本酸化ストレス学会

キーワード

• <i>Moringa oleifera</i>
• Goto-Kakizaki rat
• glucose tolerance
• diabetes
• quercetin glucoside

詳細情報

• CRID: 1390001204673230848
• NII論文ID: 130004466474
• NII論文ID: 50006541368
• DOI: 10.3164/jcbn.40.229
• COI: 1:STN:280:DC%2BD1c3jvVKmug%3D%3D
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2008033136
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可