Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-α and Interleukin-1β Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-κB and Extracellular Signal-Regulated Kinase

• Tanigawa Tetsuya

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Watanabe Toshio

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Higuchi Kazuhide

  Second Department of Internal Medicine, Osaka Medical Collage

• Machida Hirohisa

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Okazaki Hirotoshi

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Yamagami Hirokazu

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Watanabe Kenji

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Tominaga Kazunari

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Fujiwara Yasuhiro

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Oshitani Nobuhide

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

• Arakawa Tetsuo

  Department of Gastroenterology, Osaka City University Graduate School of Medicine

書誌事項

タイトル別名

• Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-.ALPHA. and Interleukin-1.BETA. Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-.KAPPA.B and Extracellular Signal-Regulated Kinase

抄録

Pathogenic bacterial components play critical roles in initiation of gastrointestinal inflammation via activation of intracellular signaling pathways which induce proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β. Lansoprazole (LANSO), a proton pump inhibitor, has been widely used for the treatment of peptic ulcers and reflux esophagitis due to its potent acid-suppressive effect. It has also been reported to have anti-inflammatory effects. In this study we investigated the effects of LANSO on the production of TNF-α and IL-1β induced by lipopolysaccharide (LPS) and Helicobacter pylori water-soluble extract (HpWE) in the human monocytic cell line (THP-1). LANSO (100 μM) significantly reduced mRNA expression and production of TNF-α and IL-1β by THP-1 cells stimulated by LPS and HpWE. LANSO inhibited phosphorylation and degradation of inhibitory factor κB-α (IκB-α) and phosphorylation of extracellular signal-regulated kinase (ERK) induced by LPS and HpWE in THP-1 cells. These findings suggest that LANSO exerts anti-inflammatory effects by suppressing induction of TNF-α and IL-1β via inhibition of nuclear factor (NF)-κB and ERK activation.<br>

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 45 (1), 86-92, 2009

  一般社団法人　日本酸化ストレス学会

キーワード

• lansoprazole
• TNF-α
• IL-1β
• NF-κB
• ERK

詳細情報

• CRID: 1390282679650762496
• NII論文ID: 130004466566
• DOI: 10.3164/jcbn.08-267
• COI: 1:CAS:528:DC%2BD1MXpvFyrsLs%3D
• ISSN: 18805086
• ISSN: 09120009
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可