Improvement of Glucose Metabolism in Patients with Impaired Glucose Tolerance or Diabetes by Long-Term Administration of a Palatinose-Based Liquid Formula as a Part of Breakfast
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- Sakuma Masae
- Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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- Arai Hidekazu
- Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, The University of Shizuoka
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- Mizuno Akira
- Departments of Clinical Biology and Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
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- Fukaya Makiko
- Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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- Matsuura Motoi
- Division of Research and Development, Food Science Institute, Meiji Dairies Corporation
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- Sasaki Hajime
- Division of Research and Development, Food Science Institute, Meiji Dairies Corporation
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- Yamanaka-Okumura Hisami
- Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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- Yamamoto Hironori
- Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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- Taketani Yutaka
- Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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- Doi Toshio
- Departments of Clinical Biology and Medicine, Institute of Health Biosciences, University of Tokushima Graduate School
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- Takeda Eiji
- Departments of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
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Abstract
A palatinose-based liquid formula (palatinose-formula), suppresses postprandial plasma glucose and insulin levels in healthy men. The objective of this study was to investigate the effects of long-term palatinose-formula ingestion on glucose metabolism in patients with impaired glucose tolerance (IGT) or type 2 diabetes. Two patients with IGT and 7 patients with type 2 diabetes participated in the palatinose-formula and dextrin-based liquid formula (dextrin-formula) loading test and long-term palatinose-formula administration study. After a 3-month control period, palatinose-formula (1046 kJ) was ingested daily by patients as a part of breakfast for 5 months. In the loading test, palatinose-formula suppressed postprandial plasma glucose and insulin levels and areas under the curve compared with those after dextrin-formula ingestion. In the long-term study, glycated hemoglobin levels (after 3 months and 5 months of treatment) and serum 8-hydroxydeoxyguanosine levels (after 5 months of treatment) were markedly decreased comparing with those at baseline. Intake of 1046 kJ palatinose-formula as a part of breakfast over a long-term period may be effective for improvement of glucose metabolism in patients with IGT or type 2 diabetes.<br>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 45 (2), 155-162, 2009
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Details 詳細情報について
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- CRID
- 1390282679649202304
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- NII Article ID
- 130004466575
- 10027737205
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed