Preliminary Trial of Rebamipide for Prevention of Low-Dose Aspirin-Induced Gastric Injury in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study

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Author(s)

    • Ono Shouko
    • Division of Endoscopy, Hokkaido University Hospital
    • Takeda Hiroshi
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Asaka Masahiro
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Imai Aki
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Yoshida Takeshi
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Hirota Jyojyo
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Hata Tamotsu
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Takagi Kikuko
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Kamada Go
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine
    • Ono Yuji
    • Department of Gastroenterology, Hokkaido University Graduate School of Medicine

Abstract

Although low-dose aspirin is widely used, since it is a cheap and effective means of prevention of cardiovascular events, it can cause hemorrhagic gastrointestinal complications. The aim of this study was to evaluate the efficacy of rebamipide in preventing low-dose aspirin-induced gastric injury. A randomized, double-blind, placebo-controlled, crossover trial was performed in twenty healthy volunteers. Aspirin 81 mg was administered with placebo or rebamipide 300 mg three times daily for 7 consecutive days. The rebamipide group exhibited significant prevention of erythema in the antrum compared with the placebo group (<i>p</i> = 0.0393, respectively). Results for the body and fornix did not differ significantly between the placebo and rebamipide groups. In conclusion, short-term administration of low-dose aspirin induced slight gastric mucosal injury in the antrum, but not in the body or fornix. Rebamipide may be useful for preventing low-dose aspirin-induced gastric mucosal injury, especially which confined to the antrum.<br>

Journal

  • Journal of Clinical Biochemistry and Nutrition

    Journal of Clinical Biochemistry and Nutrition 45(2), 248-253, 2009

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Codes

  • NII Article ID (NAID)
    130004466587
  • Text Lang
    ENG
  • ISSN
    0912-0009
  • Data Source
    J-STAGE 
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