Preliminary Trial of Rebamipide for Prevention of Low-Dose Aspirin-Induced Gastric Injury in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study

DOI 9 Citations 30 References
  • Ono Shouko
    Division of Endoscopy, Hokkaido University Hospital
  • Kato Mototsugu
    Division of Endoscopy, Hokkaido University Hospital
  • Imai Aki
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Yoshida Takeshi
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Hirota Jyojyo
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Hata Tamotsu
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Takagi Kikuko
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Kamada Go
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Ono Yuji
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Nakagawa Manabu
    Division of Endoscopy, Hokkaido University Hospital
  • Nakagawa Souichi
    Division of Endoscopy, Hokkaido University Hospital
  • Shimizu Yuichi
    Division of Endoscopy, Hokkaido University Hospital
  • Takeda Hiroshi
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine
  • Asaka Masahiro
    Department of Gastroenterology, Hokkaido University Graduate School of Medicine

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Abstract

Although low-dose aspirin is widely used, since it is a cheap and effective means of prevention of cardiovascular events, it can cause hemorrhagic gastrointestinal complications. The aim of this study was to evaluate the efficacy of rebamipide in preventing low-dose aspirin-induced gastric injury. A randomized, double-blind, placebo-controlled, crossover trial was performed in twenty healthy volunteers. Aspirin 81 mg was administered with placebo or rebamipide 300 mg three times daily for 7 consecutive days. The rebamipide group exhibited significant prevention of erythema in the antrum compared with the placebo group (p = 0.0393, respectively). Results for the body and fornix did not differ significantly between the placebo and rebamipide groups. In conclusion, short-term administration of low-dose aspirin induced slight gastric mucosal injury in the antrum, but not in the body or fornix. Rebamipide may be useful for preventing low-dose aspirin-induced gastric mucosal injury, especially which confined to the antrum.<br>

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