Nucleoprotein Diet Ameliorates Arthritis Symptoms in Mice Transgenic for Human T-Cell Leukemia Virus Type I (HTLV-1)
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- Ohtaki Hirokazu
- Department of Anatomy, Showa University School of Medicine
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- Yofu Sachiko
- Department of Anatomy, Showa University School of Medicine Gene Trophology Research Institute Anti-aging Medicine Funded Research Labs, Showa University School of Medicine
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- Nakamachi Tomoya
- Department of Anatomy, Showa University School of Medicine
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- Satoh Kazue
- Department of Anatomy, Showa University School of Medicine Anti-aging Medicine Funded Research Labs, Showa University School of Medicine
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- Shimizu Ai
- Department of Anatomy, Showa University School of Medicine
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- Mori Hiroyoshi
- Department of Anatomy, Showa University School of Medicine
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- Sato Atsushi
- Department of Anatomy, Showa University School of Medicine
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- Iwakura Yoichiro
- The Institute of Medical Science, Laboratory of Animal Research Center, The University of Tokyo
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- Matsunaga Masaji
- Gene Trophology Research Institute
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- Shioda Seiji
- Department of Anatomy, Showa University School of Medicine Anti-aging Medicine Funded Research Labs, Showa University School of Medicine
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Abstract
Because rheumatoid arthritis (RA), an autoimmune disease, the patients often recognize side-effects due to the medication, alternative therapeutic strategies might potentially offer a clinical advantage. We evaluated the effect of nucleoprotein from salmon soft roe on animal model of arthritis. Mice transgenic for human T-cell leukemia virus type I (HTLV-1 Tg) were divided into three experimental groups and supplemented on either nucleoprotein-free (nonNP), or 0.6% or 1.2% nucleoprotein mixed (NP0.6 or NP1.2) diet for 3 months. The mice were evaluated arthritis by morphology, and measured with rheumatoid factor (RF). Moreover, macrophages and oxidative metabolites were assessed in the ankle and/or serum. Anti-oxidative potentials in nucleoprotein were determined with biological anti-oxidative potential (BAP) test, and electron spin resonance (ESR) analysis. NonNP-diet HTLV-1 Tg mice increased an arthritis symptoms and RF. The symptoms were ameliorated in NP-diet groups. Macrophages detected by F4/80 staining, and oxidative metabolites in the serum and/or joints were clearly decreased in 1.2% NP-diet HTLV-1 Tg mice. Nucleoprotein and DNA-nucleotide, but less protamine, had direct anti-oxidative potency with BAP test and/or ESR in vitro. These observations suggest that dietary nucleoprotein ameliorates arthritis symptoms in HTLV-1 Tg mice and offers hope as an alternative treatment for this debilitating medical condition.<br>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 46 (2), 93-104, 2010
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Details 詳細情報について
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- CRID
- 1390282679649175424
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- NII Article ID
- 130004466611
- 50007483360
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed