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- Seino Satoshi
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Tanaka Yurie
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Honma Taro
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Yanaka Miyuki
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Sato Kenta
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Shinohara Nahoko
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Ito Junya
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Tsuduki Tsuyoshi
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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- Nakagawa Kiyotaka
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agriculture, Tohoku University
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- Miyazawa Teruo
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agriculture, Tohoku University
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- Ikeda Ikuo
- Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
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抄録
Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid β-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.<br>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
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Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 50 (2), 152-157, 2012
一般社団法人 日本酸化ストレス学会
