The effects of <i>Lactobacillus pentosus</i> strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: a randomized, double-blind, placebo-controlled trial
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- Shimizu Kazuhiro
- Sports Research & Development Core, University of Tsukuba
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- Sato Hironori
- Research & Development Department, Tsukuba Wellness Research Co., Ltd.
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- Suga Yoko
- Research & Development Department, Tsukuba Wellness Research Co., Ltd.
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- Yamahira Satoko
- Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Toba Masamichi
- Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Hamuro Koji
- Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Kakumoto Keiji
- Information Management Office, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Co., Ltd.
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- Kohda Noriyuki
- Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
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- Akama Takao
- Faculty of Sport Sciences, Waseda University
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- Kono Ichiro
- Graduate School of Comprehensive Human Sciences, Doctoral Program of Sports Medicine, University of Tsukuba
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- Kuno Shinya
- Graduate School of Comprehensive Human Sciences, Doctoral Program of Sports Medicine, University of Tsukuba
Bibliographic Information
- Other Title
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- The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: a randomized, double-blind, placebo-controlled trial
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Abstract
The purpose of the study was to evaluate the effects of Lactobacillus pentosus strain b240 (b240) intake and appropriate physical training on salivary secretory immunoglobulin A secretion in elderly adults with low physical fitness. Elderly adults with low physical fitness (daily step count below 3,500 steps) were divided into 2 groups: a b240 intake + exercise group (b240 group) and a placebo intake + exercise group (placebo group). Each subject continued intake of b240 or placebo and moderate-intensity resistance exercise for 12 weeks. Before and 4, 8, and 12 weeks after the start of intervention, each subject underwent saliva sampling. Before and after intervention, physical fitness tests and step count were measured. Our results showed that secretory immunoglobulin A secretion in 57 subjects during the b240/placebo intake period was significantly greater in the b240 group than in the placebo group (p<0.05). There were no significant changes in physical fitness tests before and after intervention in the 2 groups. The daily amount of walking increased significantly after intervention in both groups (p<0.05). These results suggest that in elderly adults with low physical activity and fitness, intake of b240 with appropriate physical exercise elevate salivary secretory immunoglobulin A secretion.
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 54 (1), 61-66, 2014
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