Oxidized DJ-1 as a possible biomarker of Parkinson’s disease

• Saito Yoshiro

  Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Medical and Life Sciences, Doshisha University

Abstract

Parkinson’s disease is a progressive, age-related, neurodegenerative disorder, and oxidative stress is an important mediator in its pathogenesis. DJ-1 is a causative gene of a familial form of Parkinson’s disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress. DJ-1 undergoes preferential oxidation at the cysteine residue at position 106, Cys-106, under oxidative stress. The critical role of Cys-106 in the biological function of DJ-1 has been demonstrated, and recent studies indicate that DJ-1 acts as a sensor of oxidative stress by regulating the gene expression of antioxidative defense. Specific antibodies against Cys-106-oxidized DJ-1 have been developed, and the generation of oxidized DJ-1 in cellular and animal models of Parkinson’s disease has been investigated. This review focuses on the role of DJ-1 in antioxidative defense and the importance of oxidizable Cys-106 in its function. The significance of the identification of early-phase Parkinson’s disease biomarkers and the nature of oxidized DJ-1 as a biomarker for Parkinson’s disease are discussed here.

Journal

• Journal of Clinical Biochemistry and Nutrition

  Journal of Clinical Biochemistry and Nutrition 54 (3), 138-144, 2014

  SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Keywords

• DJ-1
• Parkinson’s disease
• oxidative stress
• cysteine
• sulfonic acid

Details

• CRID: 1390282679650210560
• NII Article ID: 130004466748
• DOI: 10.3164/jcbn.13-108
• ISSN: 18805086
• ISSN: 09120009
• PubMed: 24894116
• Web Site: https://search.jamas.or.jp/link/ui/2015033128
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed