Dietary combination of sucrose and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats through specific modification of fatty acid composition

DOI 3 Citations 40 References Open Access
  • Ohminami Hirokazu
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Amo Kikuko
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Taketani Yutaka
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Sato Kazusa
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Fukaya Makiko
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Uebanso Takashi
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Arai Hidekazu
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School Department of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences & Graduate School of Integrated Pharmaceutical and Nutritional Sciences, The University of Shizuoka
  • Koganei Megumi
    Nutrition Research Department, Food Science Research Laboratories, Meiji Co., Ltd.
  • Sasaki Hajime
    Nutrition Research Department, Food Science Research Laboratories, Meiji Co., Ltd.
  • Yamanaka-Okumura Hisami
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Yamamoto Hironori
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Takeda Eiji
    Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School

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Abstract

A dietary combination of sucrose and linoleic acid strongly contributes to the development of metabolic disorders in Zucker fatty rats. However, the underlying mechanisms of the metabolic disorders are poorly understood. We hypothesized that the metabolic disorders were triggered at a stage earlier than the 8 weeks we had previously reported. In this study, we investigated early molecular events induced by the sucrose and linoleic acid diet in Zucker fatty rats by comparison with other combinations of carbohydrate (sucrose or palatinose) and fat (linoleic acid or oleic acid). Skeletal muscle arachidonic acid levels were significantly increased in the sucrose and linoleic acid group compared to the other dietary groups at 4 weeks, while there were no obvious differences in the metabolic phenotype between the groups. Expression of genes related to arachidonic acid synthesis was induced in skeletal muscle but not in liver and adipose tissue in sucrose and linoleic acid group rats. In addition, the sucrose and linoleic acid group exhibited a rapid induction in endoplasmic reticulum stress and abnormal lipid metabolism in skeletal muscle. We concluded that the dietary combination of sucrose and linoleic acid primarily induces metabolic disorders in skeletal muscle through increases in arachidonic acid and endoplasmic reticulum stress, in advance of systemic metabolic disorders.

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