Tempol intake improves inflammatory status in aged mice

• Yamato Mayumi

  Innovation Center for Medical Redox Navigation, Kyushu University

• Ishimatsu Ayumi

  Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University

• Yamanaka Yuuki

  Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University

• Mine Takara

  Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University

• Yamada Kenichi

  Department of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University JST, PRESTO

抄録

Oxidative stress is associated with both healthy aging and age-related disease states. In connection with oxidative stress, immunity is also a major component as a result of the chronic, low-grade inflammation associated with the development of tissue aging. Here we show that long-term treatment with the antioxidant tempol extends life-span in mice. Tempol-treated mice exhibited a reduction in mortality at 20 months. Tempol drinking did not have any effect on body weight, amount of visceral adipose tissue, or plasma biochemical parameters in aged mice. Body temperature of aged control mice (which drank only water) was significantly lower than young mice, but this reduction of body temperature was partially restored in aged mice which drank tempol. Plasma thiobarbituric acid-reactive substances and C-reactive protein were significantly increased in the control aged mice compared with young mice, but levels of both were normalized by tempol drinking. One of the endogenous antioxidants, ascorbic acid, was significantly increased in the plasma of mice which consumed tempol. The proportion of CD4 lymphocytes in the blood of aged tempol-treated mice was partially increased in comparison to aged control mice. These results suggest that the reduction of mortality by tempol is due to amelioration of chronic inflammation and improved function of the immune system through antioxidant effects.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 55 (1), 11-14, 2014

  一般社団法人　日本酸化ストレス学会

キーワード

• oxidative stress
• antioxidant
• aging
• inflammation
• immunity

詳細情報

• CRID: 1390001204672537344
• NII論文ID: 130004466767
• DOI: 10.3164/jcbn.14-4
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2015113741
• 本文言語コード: en
• データソース種別:
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