Histochemical examinations on cortical bone regeneration induced by thermoplastic bioresorbable plates applied to bone defects of rat calvariae

• KOJIMA Taku

  Divisions of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences Divisions of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences Center for Transdisciplinary Research, Niigata University

• FREITAS Paulo H L

  Divisions of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences Center for Transdisciplinary Research, Niigata University

• UBAIDUS Sobhan

  Divisions of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences Center for Transdisciplinary Research, Niigata University

• SUZUKI Akiko

  Divisions of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences

• LI Minqi

  Center for Transdisciplinary Research, Niigata University

• YOSHIZAWA Michiko

  Divisions of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences

• ODA Kimimitsu

  Divisions of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences Center for Transdisciplinary Research, Niigata University

• MAEDA Takeyasu

  Divisions of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences Center for Transdisciplinary Research, Niigata University

• KUDO Akira

  Department of Biological Information, Tokyo Institute of Technology

• SAITO Chikara

  Divisions of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences

• AMIZUKA Norio

  Center for Transdisciplinary Research, Niigata University

抄録

We aimed to histologically elucidate whether bioresorbable plates (DeltaSystem®) can induce cortical bone formation, which is essential for long-lasting bone augmentation. Standardized bone defects in rat calvariae were covered with a convexly-shaped DeltaSystem® plate, and then processed for histological observations. At 1 week, alkaline phosphatase-positive osteoblasts were seen in the newly-formed bone extending from the cavity's bottom, indicating accelerated osteogenesis. A thick layer of soft connective tissue positive for periostin, a hallmark of periosteum, covered this new bone. At 2 weeks, a spongy bone had filled the cavity up to half its height. The inner layer of the soft tissue facing the spongy bone revealed abundant periostin and osteopontin, and had many tartrate-resistant acid phosphatase-positive osteoclasts. At 4 weeks, this layer had given rise to thin new bony matrices without relation to the spongy bone arising from the cavity. These bone matrices had been thickened by 8 weeks, and turned into a thick cortical bone outlining the regenerated bone at 12 weeks. Thus, our study has provided histological evidences of cortical osteogenesis when DeltaSystem® plates are used for bone augmentation procedures.

収録刊行物

• Biomedical Research

  Biomedical Research 28 (4), 219-229, 2007

  バイオメディカルリサーチプレス

キーワード

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

詳細情報

• CRID: 1390282679877158528
• NII論文ID: 130004470687
• NII論文ID: 80018283429
• DOI: 10.2220/biomedres.28.219
• ISSN: 1880313X
• ISSN: 03886107
• Web Site: https://search.jamas.or.jp/link/ui/2008064691
• 本文言語コード: en
• データソース種別:
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