Potentiation of osteoclastogenesis by adipogenic conversion of bone marrowderivedmesenchymal stem cells
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- MORI Keisuke
- Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- SUZUKI Keiji
- Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- HOZUMI Akira
- Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto,Nagasaki 852-8501, Japan
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- GOTO Hisataka
- Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto,Nagasaki 852-8501, Japan
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- TOMITA Masato
- Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto,Nagasaki 852-8501, Japan
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- KOSEKI Hironobu
- Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto,Nagasaki 852-8501, Japan
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- YAMASHITA Shunichi
- Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- OSAKI Makoto
- Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto,Nagasaki 852-8501, Japan
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抄録
Bone marrow-derived mesenchymal stem cells (BMSCs) are the indispensable component of thebone marrow, being the common precursors for adipocytes and osteoblasts. We show here that adipogenicdifferentiation resulted in increase in the production of adipocyte markers, such as adiponectin,fatty-acid binding proteins (FABP4), peroxisome proliferator-activated receptor γ (PPARγ),as well as the receptor activator of nuclear-κB ligand (RANKL). Co-culture of osteoclast precursors(OCPs) with BMSCs-derived adipocytes significantly enhanced osteoclast differentiation withlow-dose RANKL, whose levels alone could not promote osteoclastogenesis. These results demonstratefor the first time that adipogenic differentiation of BMSCs plays a pivotal role in maintainingbone homeostasis.
収録刊行物
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- Biomedical Research
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Biomedical Research 35 (2), 153-159, 2014
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