Age-related Differences in Localization of Beta-defensin-2 in Human Gingival Epithelia
-
- Matsuzaka Kenichi
- Oral Health Science Center HRC7, Tokyo Dental College
-
- Sato Daisuke
- Oral Health Science Center HRC7, Tokyo Dental College
-
- Ishihara Kazuyuki
- Oral Health Science Center HRC7, Tokyo Dental College
-
- Hashimoto Sadamitsu
- Oral Health Science Center HRC7, Tokyo Dental College
-
- Yoshinari Masao
- Oral Health Science Center HRC7, Tokyo Dental College
-
- Katakura Akira
- Oral Health Science Center HRC7, Tokyo Dental College
-
- Inoue Takashi
- Oral Health Science Center HRC7, Tokyo Dental College
Search this article
Abstract
Defensins are known to play an important role in defense against bacteria. It is also known that immunity against infection is compromised with age. The purpose of this study was to evaluate the localization of human beta-defensin (HBD)-2 in human gingival epithelia according to age. Gingival epithelia in maxillary premolar buccal normal regions was immunohistochemically stained for HBD-2. Specimens were divided into two groups: 6 cases in a young group (<20 years old) and 7 cases in an elderly group (>50 years old). Expression of HBD-2 in gingival epithelium in young subjects was mostly detected in the superficial layer of the parakeratinized layer, while some areas of the spinous cell layer in elderly subjects were positive for HBD-2, as was the superficial layer. Two cases in the young group and 5 cases in the elderly group immunoreacted with HBD-2 in the spinous cell layer. Furthermore, immunoreaction was stronger in the elderly group. The results revealed HBD-2 positive cells in spinous cells in the elderly group and in the parakeratinized layer in the young group.
Journal
-
- The Bulletin of Tokyo Dental College
-
The Bulletin of Tokyo Dental College 47 (4), 167-170, 2006
Tokyo Dental College, Japan
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679565942016
-
- NII Article ID
- 130004471638
-
- ISSN
- 00408891
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed