皮膚カンジダ症に対するピマフシン軟膏の治験:18施設における共同研究成績の綜合 [in Japanese] Cutaneous Candidiasis treated with Pimaricin Ointment:Summerized Data collaborated with 18 Dermatological Clinics [in Japanese]
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抗カンジダ性抗生物質ピマリシンにつき，4施設で試験管内抗菌価を測定，C. albicansに対してはMICが3.12∼6.25 mcg/mlの範囲に集中した。白癬菌に対しては50∼100 mcg/ml以上であつた。18施設が行なつたピマフシン軟膏(2%にピマリシンを含む)の治験では，カンジダ性間擦疹23例の有効率65.3%，乳児寄生菌性紅斑6例の有効率83.3%口角糜爛5例の有効率80%，外陰膣カンジダ症12例の有効率66.6%，指間糜爛53例の有効率64.2%，爪囲炎71例の有効率52.1%で，全170例の有効率は60.6%であつた。副作用は170例中8例(4.7%で，軽い刺激症状がみられたのみであつた。
The antifungal activity of Pimaricin was studied by 4 dermatological clinics. The results showed that the Pimaricin had the M. I. C. against Candida albicans of 3.12∼6.25 mcg/ml, but against Trichophyton mentagrophytes and Trichophyton rubrum of 50∼100 mcg/ml. Altogether, 170 patients were treated with 2% Pimaricin ointment. Of the 23 patients with intertriginous candidiasis 15 (65.3%) were improved. Of the 6 patients with infantile intertriginous candidiasis (Erythema mycoticum infantile), five (83.3%) were improved. Of the 5 patients with monilial perléche, 4 (80%) were improved. Of the 12 patients with candidal vaginitis, 8 (66.6%) were improved. Of the 53 patients with interdigital candidiasis, 34 (64.2%) were improved. And of the 71 patients with paronychial candidiasis, 37 (52.1%) were improved. Totally of the 170 patients, 103 (60.6%) were improved. Eight (4.7%) of the patients treated observed local irritation or burning, with only one patient noting contact dermatitis due to Pimaricin.
- Nishi Nihon Hifuka
Nishi Nihon Hifuka 31(5), 509-529, 1969
Western Division of Japanese Dermatological Association