Prospective study of atopic status in infants of the cohort in Tokyo, Japan

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  • Iwata Tsutomu
    Department of Pediatrics, Mejirodai Campus, University of Tokyo
  • Hayakawa Hiroshi
    Department of Pediatrics, Mejirodai Campus, University of Tokyo
  • Komoda Fusako
    Department of Pediatrics, Mejirodai Campus, University of Tokyo
  • Koseki Masae
    Department of Public Health and Health Centre, Office of Bunkyo-District
  • Miyakawa Tatsuko
    Department of Public Health and Health Centre, Office of Bunkyo-District
  • Sakurayama Toyoo
    Department of Public Health and Health Centre, Office of Bunkyo-District
  • Yamasaki Kaeko
    Department of Public Health and Health Centre, Office of Bunkyo-District
  • Honjou Michie
    Department of Pediatrics, Second Hospital of Tokyo Women's Medical College
  • Hirakawa Noriko
    Department of Pediatrics, Second Hospital of Tokyo Women's Medical College
  • Inoue Kazuko
    Department of Pediatrics, Tokyo Metropolitan Hiroo Hospital
  • Hohashi Naohiro
    Department of Family Nursing, Faculty of Medicine, University of Tokyo
  • Sugishita Chieko
    Department of Family Nursing, Faculty of Medicine, University of Tokyo

抄録

Several risk factors for the development of allergic diseases are considered including, for example, the level of IgE in cord blood or in the peripheral blood of neonates and the antigenic effect of some foods that are ingested by both babies and mothers during pregnancy and during the lactation period. However, not all infants with atopic diathesis develop allergic diseases. To clarify the risk factors and the mechanism for developing allergic diseases, particularly bronchial asthma (BA), we prospectively investigated atopic diatheses and symptoms in children in a cohort using a questionnaire method. The factors correlated to development of allergic diseases, as a whole, at the age of 5-6 years were atopic family history and any allergic symptom at 4 months of age. However, not all subjects with atopic dermatitis developed BA later on. High levels of total IgE and positive IgE antibody against egg white were not risk factors for developing BA at the age of 5-6 years.

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