Urinary leukotriene E4 and 11-dehydro-thromboxane B2 excretion in children with bronchial asthma

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Author(s)

    • Yoshikawa Kaori
    • Department of Pediatrics, Graduate School of Medicine, Gifu University
    • Kondo Naomi
    • Department of Pediatrics, Graduate School of Medicine, Gifu University
    • Matsui Eiko
    • Department of Pediatrics, Graduate School of Medicine, Gifu University
    • Inoue Ryosuke
    • Department of Pediatrics, Graduate School of Medicine, Gifu University
    • Kaneko Hideo
    • Department of Pediatrics, Graduate School of Medicine, Gifu University
    • Aoki Minako
    • Department of Pediatrics, Graduate School of Medicine, Gifu University
    • Kasahara Kimiko
    • Department of Pediatrics, Graduate School of Medicine, Gifu University

Abstract

<b>Background:</b> Cysteinyl leukotrienes (CysLTs) and thromboxane (TX) A<sub>2</sub> have been implicated in the pathogenesis of bronchial asthma. Urinary leukotriene E<sub>4</sub> (LTE<sub>4</sub>) and 11-dehydro-TXB<sub>2</sub> (11DTXB<sub>2</sub>) levels are often used to assess the production of CysLTs and TXA<sub>2</sub>. However, few studies have examined the products of these two mediators in the same asthmatic patients. To define the potential roles of CysLTs and TXA<sub>2</sub> in the pathogenesis of bronchial asthma in children, their urinary levels were measured in the present study.<br> <b>Methods:</b> Urinary LTE<sub>4</sub> and 11DTXB<sub>2</sub> levels were measured by enzyme immunoassay (EIA) and radioimmunoassay (RIA), respectively. Urine samples from asthmatic children were measured during the stable condition and during an acute attack.<br> <b>Results:</b> Urinary LTE<sub>4</sub> levels during an acute attack (median 476 pg/mg creatinine; range 191-1100 pg/mg creatinine) and during the stable condition (median 332 pg/mg creatinine; range 128-965 pg/mg creatinine) were significantly higher (<i>P</i><0.05) than those of controls (median 233 pg/mg creatinine; range 103-389 pg/mg creatinine). Urinary 11DTXB<sub>2</sub> levels during an acute attack and during the stable condition (median 1666 (range 110-5105) and 1009 (range 46-6070) pg/mg creatinine, respectively) were significantly higher (<i>P</i><0.05) than those of controls (median 252 pg/mg creatinine; range 41-716 pg/mg creatinine). Comparing different stages of asthma, LTE<sub>4</sub> levels during an acute attack were significantly higher (<i>P</i><0.05) than during the stable condition; however, there was no difference in urinary TXB<sub>2</sub> levels.<br> <b>Conclusions:</b> The present findings suggest that high levels of CysLTs and TXA<sub>2</sub> are associated with the pathogenesis of bronchial asthma. The measurement of urinary LTE<sub>4</sub> and 11DTXB<sub>2</sub> would be useful in understanding the individual pathogenesis of asthmatic children.<br>

Journal

  • Allergology International

    Allergology International 53(2), 127-134, 2004

    Japanese Society of Allergology

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