Drug Compliance in Patients with Bronchial Asthma: Relation among Compliance with Different Types of Antiasthmatic Drug and Association with Daily Administration Frequency

• Hasegawa Takashi

  Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences

• Suzuki Eiichi

  Department of General Medicine, Niigata University Medical and Dental Hospital

• Toyabe Shinichi

  Department of Medical Informatics, Niigata University Medical and Dental Hospital

• Akazawa Kouhei

  Department of Medical Informatics, Niigata University Medical and Dental Hospital

• Kawano Kenji

  Department of Pharmacy, Niigata University of Pharmacy and Applied Life Sciences

• Haraguchi Michihiko

  Division of Respiratory Medicine, Niigata City General Hospital

• Toyama Joji

  Division of Respiratory Medicine, Joetsu General Hospital

• Watanabe Yoko

  Shichikuyama and Kido Branches, Niigata Pharmacy

• Watanabe Noriko

  Shichikuyama and Kido Branches, Niigata Pharmacy

• Arakawa Masaaki

  Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences

• Satoh Hiroshi

  Department of Pharmacy, Niigata University Medical and Dental Hospital

• Gejyo Fumitake

  Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences

• Niigata Inhalation Therapy Study Group

抄録

Background: Not only monotherapy with inhaled corticosteroids (ICS) but also the concurrent use of other antiasthmatic agents, including leukotriene receptor antagonists (LTRA), play an important role in the management of asthma. However, few studies have focused on compliance with these drugs and on the relation between drug compliance and drug usage.<br> Methods: Data were derived from a survey of pharmacists dispensing antiasthmatic drugs to adults with asthma who visited participating pharmacies from October through November 2002. The patients were limited to regular users of ICS whose medication had not been changed for at least 6 months before the survey. Drug compliance and the daily administration frequency of antiasthmatic agents were evaluated on the basis of pharmaceutical records.<br> Results: Completed data were received for 322 patients. ICS compliance was lower than compliance with oral sustained-released theophylline (OSRT) and compliance with LTRA. ICS compliance significantly correlated with OSRT compliance and with LTRA compliance. There were no significant differences of ICS compliance among ICS alone, ICS + LTRA, ICS + OSRT and ICS + LTRA + OSRT group, while the daily inhalation frequency in ICS + OSRT or ICS + OSRT + LTRA group were higher than those in ICS alone group. Although there was a significant negative correlation between ICS compliance and daily inhalation frequency, neither OSRT compliance nor LTRA compliance significantly correlated with the tablet or capsule numbers per day. These findings indicate that OSRT may increase the compliance of concomitant ICS, and that the compliance of OSRT or LTRA is independent of the numbers of tablets taken per day.<br> Conclusions: These unique characteristics should be considered in the treatment and guidance of patients with bronchial asthma.<br>

収録刊行物

• Allergology International

  Allergology International 54 (4), 547-553, 2005

  一般社団法人日本アレルギー学会

キーワード

• bronchial asthma
• drug compliance
• inhaled corticosteroid
• leukotriene receptor antagonist
• oral sustained-released theophylline

詳細情報

• CRID: 1390001204634257280
• NII論文ID: 130004476864
• NII論文ID: 10016880750
• NII書誌ID: AA11091750
• DOI: 10.2332/allergolint.54.547
• ISSN: 14401592
• ISSN: 13238930
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015310728?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015310728?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2006309886
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可