Asthma Phenotypes in Japanese Adults - Their Associations with the <i>CCL5</i> and <i>ADRB2</i> Genotypes
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- Kaneko Yoshiko
- Department of Pulmonary Medicine, University of Tsukuba
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- Masuko Hironori
- Department of Pulmonary Medicine, University of Tsukuba
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- Sakamoto Tohru
- Department of Pulmonary Medicine, University of Tsukuba
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- Iijima Hiroaki
- Tsukuba Medical Center
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- Naito Takashi
- Tsukuba Medical Center
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- Yatagai Yohei
- Department of Pulmonary Medicine, University of Tsukuba
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- Yamada Hideyasu
- Department of Pulmonary Medicine, University of Tsukuba
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- Konno Satoshi
- First Department of Medicine, Hokkaido University School of Medicine
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- Nishimura Masaharu
- First Department of Medicine, Hokkaido University School of Medicine
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- Noguchi Emiko
- Department of Medical Genetics, Faculty of Medicine, University of Tsukuba
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- Hizawa Nobuyuki
- Department of Pulmonary Medicine, University of Tsukuba
Bibliographic Information
- Other Title
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- Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes
- Asthma phenotypes in Japanese adults – their associations with the CCL5 and ADRB2 genotypes
- Asthma phenotypes in Japanese adults—their associations with the CCL5 ADRB2 genotypes.
- Asthma phenotypes in Japanese adults—their associations with the CCL5 and ADRB2 genotypes
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Abstract
Background: Cluster analyses were previously performed to identify asthma phenotypes underlying asthma syndrome. Although a large number of patients with asthma develop the disease later in life, these previous cluster analyses focused mainly patients with younger-onset asthma.<br> Methods: Cluster analysis examined the existence of distinct phenotypes of late-onset asthma in Japanese patients with adult asthma. We then associated genotypes at the CCL5, TSLP, IL4, and ADRB2 genes with the clusters of asthma identified.<br> Results: Using the 8 variables of age, sex, age at onset of the disease, smoking status, total serum IgE, %FEV1, FEV1/FVC, and specific IgE responsiveness to common inhaled allergens, two-step cluster analysis of 880 Japanese adult asthma patients identified 6 phenotypes: cluster A (n = 155): older age at onset, no airflow obstruction; cluster B (n = 170): childhood onset, normal-to-mild airflow obstruction; cluster C (n = 119): childhood onset, the longest disease duration, and moderate-to-severe airflow obstruction; cluster D (n = 108): older age at onset, severe airflow obstruction; cluster E (n = 130): middle-age at onset, no airflow obstruction; and cluster F (n = 198): older age at onset, mild-to-moderate airflow obstruction. The CCL5-28C>G genotype was significantly associated with clusters A, B and D (OR 1.65, p = 0.0021; 1.67, 0.018; and 1.74, 0.011, respectively). The ADRB2 Arg16Gly genotype was also associated with clusters B and D (OR 0.47, p = 0.0004; and 0.63, 0.034, respectively).<br> Conclusions: The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes. Genetic and phenotypic data have the potential to elucidate the phenotypic heterogeneity and pathophysiology of asthma.<br>
Journal
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- Allergology International
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Allergology International 62 (1), 113-121, 2013
Japanese Society of Allergology