Mucosal Immunity and the Onset of Allergic Disease
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- Ohshima Yusei
- Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
Bibliographic Information
- Other Title
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- Mucosal immunity and onset of allergic disease
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Abstract
Mucosal barriers encounter an environment that is rich in pathogens that possess mechanisms for invading mucosal tissues. These barriers also encounter innocuous antigens, such as foods, airborne antigens, and microbiota. The mucosa has developed a sophisticated immune system that can mount robust immune responses against pathogenic antigens, while maintaining mucosal tolerance against non-pathogenic antigens. Accumulating evidence indicates that the mucosal epithelium, dendritic cells, and a subtype of T cells with regulatory properties play important roles in the development and maintenance of mucosal tolerance. Moreover, the micribiota also contribute to regulating the mucosal immune system. A failure to develop or the breakdown of mucosal tolerance can result in allergic diseases, such as food allergy and asthma. By taking advantage of the unique characteristics of the mucosal immune system, strategies that induce regulatory cells in vivo and, thereby, reconstitute mucosal tolerance may be used to develop novel therapies that are suitable for treating or preventing of allergic diseases.<br>
Journal
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- Allergology International
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Allergology International 62 (3), 279-289, 2013
Japanese Society of Allergology
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Details 詳細情報について
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- CRID
- 1390001204632518528
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- NII Article ID
- 130004477200
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- COI
- 1:STN:280:DC%2BC3sbitlOkuw%3D%3D
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- ISSN
- 14401592
- 13238930
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed