Innate-Type and Acquired-Type Allergy Regulated by IL-33

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Author(s)

    • Yoshimoto Tomohiro
    • Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine
    • Matsushita Kazufumi
    • Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine

Abstract

We propose two types of allergic response: IgE-dependent and IgE-independent, and designate these as ‘acquired-type allergy’ and ‘innate-type allergy’, respectively. IL-33 stimulates both innate (basophils, mast cells, or group 2 innate lymphoid cells) and acquired (Th2 cells) allergy-related cells to induce and/or augment Th2 cytokine production, which leads to eosinophilic inflammation <i>in vivo</i>. Thus, IL-33 is an essential regulator for both ‘innate-type allergy’ and ‘acquired-type allergy’, and might be an attractive therapeutic target for allergic diseases.<br>

Journal

  • Allergology International

    Allergology International 63(Supplement.1), S3-S11, 2014

    Japanese Society of Allergology

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