Bone cements based on ground β-tricalcium phosphate with sufficient compressive strengths and short hardening time

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In this study, we investigated the hardening processes and compressive strengths of binary and ternary calcium phosphate cements based on β-tricalcium phosphate [Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>] (β-TCP) ground by a mortar grinder. The cements were prepared by adding tetracalcium phosphate [Ca<sub>4</sub>(PO<sub>4</sub>)<sub>2</sub>O] (TTCP) and/or calcium hydrogenphosphate dihydrate [CaHPO<sub>4</sub>·2H<sub>2</sub>O] (DCPD) to the ground β-TCP, which hardened on mixing with disodium hydrogenphosphate [Na<sub>2</sub>HPO<sub>4</sub>] aqueous solution. The binary cement β-TCP/TTCP with a molar ratio of 2:1 showed a compressive strength of 35 MPa after hardening, which is based on a 1-day acid–base reaction. The ternary cement β-TCP/TTCP/DCPD with molar ratios of β-TCP (50–60%), TTCP (20–30%), and DCPD (14–20%,) showed early hardening and an adequate compressive strength of 30–43 MPa after a 1-day reaction. In particular, the ternary cement with a molar ratio of 3:2:1 (β-TCP:TTCP:DCPD) showed compressive strengths of 17, 43, and 56 MPa after 1 h in air, and 1 and 7 days’ soaking in saline solution, respectively. These ternary cements hardened to give well-connected acicular apatite crystals. The hardening process involved hydrolysis of the ground β-TCP and acid–base reactions of β-TCP/TTCP and DCPD/TTCP.


  • Journal of the Ceramic Society of Japan

    Journal of the Ceramic Society of Japan 121(1416), 714-722, 2013

    The Ceramic Society of Japan


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