Effect of Different Types of Cyclodextrins on Gastrointestinal Absorption of ^|^alpha;-Lipoic Acid in Rats and Humans

DOI Web Site Web Site 参考文献45件
  • Takahashi Hideki
    Carbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd.
  • Kishino Eriko
    Carbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd.
  • Mikuni Katsuhiko
    Carbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd.
  • Kiuchi Yoshihiro
    Laboratory Animal Facility, Yokohama City University School of Medicine
  • Beppu Hidehiko
    Fujita Memorial Nanakuri Institute, Fujita Health University
  • Okazaki Hideto
    Nanakuri Sanatorium Hospital, Fujita Health University
  • Shimpo Kan
    Fujita Memorial Nanakuri Institute, Fujita Health University
  • Sonoda Shigeru
    Fujita Memorial Nanakuri Institute, Fujita Health University Nanakuri Sanatorium Hospital, Fujita Health University

書誌事項

タイトル別名
  • Effect of Different Types of Cyclodextrins on Gastrointestinal Absorption of α-Lipoic Acid in Rats and Humans

この論文をさがす

抄録

Powders of α-lipoic acid (ALA)/cyclodextrin (CD) complexes containing 9-24% (w/w) ALA were prepared to improve the gastrointestinal absorption of ALA. ALA and the ALA/CD complexes, corresponding to 30 mg/kg of body weight of ALA in rats and 600 mg of ALA in humans, were orally administered under fasting conditions. In rats, the area under the ALA plasma concentration/time-course curve from 0 to 3 h (AUC 0-3 h) for the ALA/G2-β-CD® complex was larger than that for ALA alone. In humans, after administration of 3 ALA/CD complexes with γ-CD, G2-β-CD® and Isoeleat®P, the ALA plasma concentration value 0.5 h after administration of the ALA/G2-β-CD® complex was significantly higher (p < 0.05) than that for ALA alone, and the AUC 0-3 h value for the ALA/G2-β-CD® complex was 1.4 times larger than that for ALA alone, although the difference was not significant. We suggest that the water-soluble ALA/G2-β-CD® complex powder can enhance ALA absorption in rats and humans.

収録刊行物

参考文献 (45)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ