Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease

• Nakamura Kiminori

  Department of Cell Biological Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

• Ayabe Tokiyoshi

  Department of Cell Biological Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

Abstract

The intestinal epithelial cells are replaced in every three to four days. This system is maintained by self-reproduction, differentiation of the intestinal stem cells. The continuous monolayer of intestinal epithelial cells functions in innate immunity as the primary barrier against microbial colonization. Paneth cells secrete α-defensins, and they are actively involved in the innate immunity and maintain the intestinal homeostasis by controlling intestinal microbiota. In addition, recent analyses of epithelial renewal in the intestine illustrate that Paneth cells provide survival signals to crypt intestinal stem cells. Two types of intestinal stem cells, crypt base columnar (CBC) stem cell and +4 stem cell, have been identified. Lgr5 positive CBC stem cells, Bmi1 positive +4 stem cells and Paneth cells create the stem cell niche in the small intestine. In this review, recent advances in understanding the roles of Paneth cells and stem cells which involve stem cell niche, and their association of inflammatory bowel disease were discussed and summarized.

Journal

• Inflammation and Regeneration

  Inflammation and Regeneration 32 (2), 053-060, 2012

  The Japanese Society of Inflammation and Regeneration

Keywords

• α-defensin
• crypt base columnar stem cell
• +4 stem cell
• inflammatory bowel disease
• Paneth cell

Details

• CRID: 1390282680234731008
• NII Article ID: 130004482294
• DOI: 10.2492/inflammregen.32.053
• COI: 1:CAS:528:DC%2BC38XmslKks7o%3D
• ISSN: 18808190
• ISSN: 18809693
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed