The non-canonical Wnt5a/Ror2 signaling pathway in bone metabolism

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Author(s)

    • Sonomoto Koshiro
    • The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan
    • Yamaoka Kunihiro
    • The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan
    • Tanaka Yoshiya
    • The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan

Abstract

Wingless-type MMTV integration site (Wnt) family molecules, a family of secreted glycoproteins have now gathered attention as a therapeutic target. Drug innovation targeting the canonical Wnt pathway is in the most interest since its molecular mechanism is well understood and clinical trials are in progress for osteoporosis. Recent findings have revealed the contribution of the non-canonical Wnt pathway in malignant tumors suggesting this pathway as a new treatment target, but it is relatively less understood. Recently, several reports have demonstrated the involvement of the non-canonical Wnt pathway in the bone metabolism. Therefore, we have compiled the current understanding of the non-canonical Wnt pathway in association with bone metabolism.

Journal

  • Inflammation and Regeneration

    Inflammation and Regeneration 34(2), 103-108, 2014

    The Japanese Society of Inflammation and Regeneration

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