Synthesis and Characterization of Iron Oxide Particles for Medical Applications
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Two kinds of iron oxide particles—spherical cobalt-containing iron oxide particles with spinel structure and platelet γ-Fe<sub>2</sub>O<sub>3</sub> particles—were synthesized for medical applications. The particle size of the spherical cobalt-containing iron oxide particles was about 20 nm regardless of the coercive force that was varied in the range of about 4.0 to 39.0 kA/m by varying the Co content. The size and coercive forces of the platelet γ-Fe<sub>2</sub>O<sub>3</sub> particles were in the range of about 30 to 100 nm and about 7.6 to 13.5 kA/m, respectively. The temperature-raising properties were evaluated for water dispersion of these particles under different AC magnetic fields and frequencies to apply hyperthermia or thermoablation using hysteresis-loss heating of ferrimagnetic particles. Heat generation in spherical cobalt-containing iron oxide particles was based on both hysteresis-loss and Brownian relaxation. Platelet γ-Fe<sub>2</sub>O<sub>3</sub> particles showed heat generation completely based on hysteresis-loss.
- Journal of the Japan Society of Powder and Powder Metallurgy
Journal of the Japan Society of Powder and Powder Metallurgy 61(S1), S117-S120, 2014
Japan Society of Powder and Powder Metallurgy