Simultaneous Determination of 8-hydroxydeoxyguanosine, a Marker of Oxidative Stress, and Creatinine, a Standardization Compound, in Urine

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  • KASAI Hiroshi
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • SVOBODA Peter
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • YAMASAKI Sayumi
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • KAWAI Kazuaki
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

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  • Simultaneous determination of 8-hydroxydeoyguanosine, a marker of oxidative stress, and creatinine, a standardization compound, in urine

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Abstract

Recently, H. Kasai reported an automatic, precise method of 8-hydroxydeoxyguanosine (8-OH-dG) analysis in urine by high performance liquid chromatography coupled to an electrochemical detector (HPLC-ECD). It is based on a cleaning-up step by anion-exchange chromatography and a further purification step using reverse phase chromatography before detection by the ECD. In this communication, we report a method for the simultaneous determination of 8-OH-dG and creatinine, an internal standard for normalizing the excretion of 8-OH-dG in urine.

Journal

  • Industrial Health

    Industrial Health 43 (2), 333-336, 2005

    National Institute of Occupational Safety and Health

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