酵母のヌクレオソームDNAに共通した機械的特性

• KIMURA Hajime

  Major in integrated Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University

• OHYAMA Takashi

  Major in integrated Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University

書誌事項

タイトル別名

• A common mechanical property shared by yeast nucleosomal DNAs

抄録

Mechanical properties of DNA have long been thought to play an important role in the packaging of genomic DNA in the nucleus. Using two parameter sets for the flexibility of short base-pair steps, the average flexibility profile of 199 yeast nucleosomal DNAs was calculated. Dramatically decreased flexibilities, or rigid peaks, were observed at intervals of about 10 bp in the profile. Furthermore, it was found that the phase of the rigid peaks overlapped with the phase of the high AA/TT occurrence. These results seem to indicate that periodically spaced rigid regions help DNA to contact with histone core with high affinity.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｄｖａｎｃｅｄ　Ｓｃｉｅｎｃｅ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｄｖａｎｃｅｄ　Ｓｃｉｅｎｃｅ 20 (1/2), 37-40, 2008

  Society of Advanced Science

キーワード

• nucleosome
• chromatin
• DNA flexibility
• Eukaryotic genome
• nucleus

詳細情報

• CRID: 1390001204341539712
• NII論文ID: 130004487834
• DOI: 10.2978/jsas.20.37
• ISSN: 18813917
• ISSN: 09155651
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可