Pathogenesis of Vasculitis in env-pX Rats

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    • Ishizu Akihiro
    • Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
    • Yoshiki Takashi
    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan|GeneticLab, Co., Ltd., Sapporo, Hokkaido, Japan


Transgenic rats carrying the env-pX gene of human T-cell leukemia virus type I (env-pX rats) develop necrotizing angiitis resembling human polyarteritis nodosa (PN). In the development of vasculitis in these rats, the thymus plays an important role. In this review, we provide an outline of the pathogenesis of vasculitis observed in env-pX rats, and discuss the developmental mechanism of human necrotizing angiitis such as PN with an unknown cause. (*English Translation of J Jpn Coll Angiol 2009; 49: 17-20.)


  • Annals of Vascular Diseases

    Annals of Vascular Diseases 5(3), 296-299, 2012

    The Editorial Committee of Annals of Vascular Diseases


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