Sweet Potato [Ipomoea batatas (L.) Lam. "Tainong 57"] Starch Improves Insulin Sensitivity in High-Fructose Diet-Fed Rats by Ameliorating Adipocytokine Levels, Pro-Inflammatory Status, and Insulin Signaling
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- CHEN Ya-Yen
- School of Nutrition and Health Sciences, Taipei Medical University
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- LAI Ming-Hoang
- Department of Nursing, Cardinal Tien Junior College of Healthcare and Management
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- HUNG Hsin-Yu
- School of Nutrition and Health Sciences, Taipei Medical University
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- LIU Jen-Fang
- School of Nutrition and Health Sciences, Taipei Medical University
書誌事項
- タイトル別名
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- Sweet Potato [<i>Ipomoea batatas</i> (L.) Lam. “Tainong 57”] Starch Improves Insulin Sensitivity in High-Fructose Diet-Fed Rats by Ameliorating Adipocytokine Levels, Pro-Inflammatory Status, and Insulin Signaling
- Sweet Potato [Ipomoea batatas (L.) Lam. ^|^ldquo;Tainong 57^|^rdquo;] Starch Improves Insulin Sensitivity in High-Fructose Diet-Fed Rats by Ameliorating Adipocytokine Levels, Pro-Inflammatory Status, and Insulin Signaling
- Liu, Sweet potato [Ipomoea batatas (L.) Lam. "Tainong 57"] starch improves insulin sensitivity in high-fructose diet-fed rats by ameliorating adipocytokine levels, pro-inflammatory status, and insulin signaling
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The aim of this study was to investigate the effects of low-glycemic index (GI) sweet potato starch on adipocytokines, pro-inflammatory status, and insulin signaling in the high-fructose diet-induced insulin-resistant rat. We randomly divided 24 insulin-resistant rats and 16 normal rats into two groups fed a diet containing 575 g/kg of starch: a low-GI sweet potato starch (S) or a high-GI potato starch (P). The four experimental groups were labeled as follows: insulin-resistant P (IR-P), insulin-resistant S (IR-S), normal P (N-P) and normal S (N-S). After 4 wk on the experimental diets, an intraperitoneal glucose tolerance test (IPGTT) was conducted, and the homeostasis model assessment (HOMA), adipocytokines, pro-inflammatory cytokines levels, and insulin signaling-related protein expression were measured. The homeostasis model assessment values were significantly lower in the IR-S than in the IR-P group, suggesting that insulin sensitivity was improved among sweet potato starch-fed rats. Levels of tumor necrosis factor-α, interleukin-6, resistin, and retinol binding protein-4 were significantly lower in the IR-S versus the IR-P group, indicating an improvement of pro-inflammatory status in sweet potato starch-fed rats. The sweet potato starch diet also significantly enhanced the protein expression of phospho-Tyr-insulin receptor substrate-1 and improved the translocation of glucose transporter 4 in the skeletal muscle. Our results illustrated that sweet potato starch feeding for 4 wk can improve insulin sensitivity in insulin-resistant rats, possibly by improving the adipocytokine levels, pro-inflammatory status, and insulin signaling.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 59 (4), 272-280, 2013
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詳細情報 詳細情報について
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- CRID
- 1390001206324721280
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- NII論文ID
- 130004491349
- 40019766021
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC3sXhsVegs7%2FE
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 024801529
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- PubMed
- 24064727
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可