Differential effects of neonatal maternal separation on the expression of neurotrophic factors in rat brain. II: Regional differences in the cerebellum versus the cerebral cortex

• MIKI Takanori

  Departments of Anatomy and Neurobiology, Kagawa University

• LEE Kyoung-Youl

  Department of Health Science, Kongju National University

• YOKOYAMA Toshifumi

  Departments of Bioresource and Agrobiosciences, Kobe University

• LIU Jun-Qian

  Departments of Anatomy and Neurobiology, Kagawa University

• KUSAKA Takashi

  Departments of Pediatrics, Kagawa University

• SUZUKI Shingo

  Departments of Anatomy and Neurobiology, Kagawa University

• OHTA Ken-ichi

  Departments of Anatomy and Neurobiology, Kagawa University

• WARITA Katsuhiko

  Departments of Anatomy and Neurobiology, Kagawa University

• JAMAL Mostofa

  Departments of Forensic Medicine, Kagawa University

• UEKI Masaaki

  Department of Anesthesia, Nishiwaki Municipal Hospital

• YAKURA Tomiko

  Departments of Anatomy and Neurobiology, Kagawa University

• HOSOMI Naohisa

  Department of Clinical Neuroscience and Therapeutics, Hiroshima University

• TAKEUCHI Yoshiki

  Departments of Anatomy and Neurobiology, Kagawa University

Abstract

This study was conducted in order to examine the effects of early postnatal maternal separation stress on the age-dependent fluctuations in the expression levels of neurotrophic factor ligands and receptors in the developing cerebellum. Wistar rats were separated from their mothers for 3 h each day during postnatal days (PND) 10 to 15. The expression level of mRNA for brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), insulin-like growth factor-1 (IGF-1), and type-1 IGF receptor (IGF-1R) were evaluated in the cerebellum on PND16, 20, 30, and 60 with real-time RT-PCR. The mRNA levels of cerebellar BDNF in maternally separated rats were increased on PND16, while the other variables showed no significant alterations at any of the time points examined. However, the effects of an identical maternal separation on the cerebral cortex were previously reported to be completely different. These results indicate regional differences in the responses of neurotrophic factor ligands/receptors between the cerebellum and cerebral cortex. Given that neurotrophic factors play important roles in brain development, alterations in these factors may interrupt normal brain development and ultimately, lead to functional disruptions.

Journal

• Okajimas Folia Anatomica Japonica

  Okajimas Folia Anatomica Japonica 90 (3), 53-58, 2013

  Editorial Board of Okajimas Folia Anatomica Japonica

Keywords

• brain development
• cerebellum
• maternal separation
• neurotrophic factor

Details

• CRID: 1390282681297868800
• NII Article ID: 130004495127
• DOI: 10.2535/ofaj.90.
• COI: 1:STN:280:DC%2BC2crnsVWltw%3D%3D
• ISSN: 18811736
• ISSN: 0030154X
• PubMed: 24670490
• Web Site: https://search.jamas.or.jp/link/ui/2015095923
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed