非アルコール性脂肪肝炎(NASH)における性差と年齢の関与―生活習慣病,脂肪測定,アディポサイトカイン,遺伝子多型を中心に―  [in Japanese] Characteristics of gender differences and age in nonalcoholic steatohepatitis with regard to the complications of lifestyle-related disease, fat distribution, adipocytokines and SNPs  [in Japanese]

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Author(s)

    • 小木曽 智美 Kogiso Tomomi
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University
    • 白鳥 敬子 Shiratori Keiko
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University
    • 千嶋 さやか Chishima Sayaka
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University
    • 児玉 和久 Kodama Kazuhisa
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University
    • 戸張 真紀 Tobari Maki
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University
    • 松下 典子 Matsushita Noriko
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University
    • 谷合 麻紀子 Taniai Makiko
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University
    • 鳥居 信之 Torii Nobuyuki
    • 東京女子医科大学消化器内科 Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University

Abstract

非アルコール性脂肪肝炎(NASH)における,性別・年齢の関与を明らかにするため,組織学的に診断されたNASH 691例を55歳を境に年齢(若年Y・高齢E)と性別(男M・女F)で4群に群別し,臨床病理学的特徴,脂肪測定,血清adipocytokine,遺伝的因子を比較検討した.高度肥満例は若年群で有意に高頻度であった(高度肥満YM 10%,EM 2%,YF 13%,EF 5%).男女とも高齢になると生活習慣病の合併,線維化の進行を認めた.CTによる脂肪測定では,性別・年齢で内臓脂肪面積は有意差を認めなかった.肝硬変合併に関与する多変量解析では,4群全てにおいて脂質異常症非合併が肝硬変合併の有意因子として抽出された.さらにEF群では糖尿病が有意な危険因子であった.adiponectinはEF群で高値で,血清IL-6はYF群で低値であった.NASHでは性・年齢により病態が異なり,これらを考慮して診療にあたる必要がある.

The development of nonalcoholic steatohepatitis (NASH) was found to be influenced by gender differences and age. To elucidate the characteristics of NASH, we first categorized subjects according to age (55 and over vs. under 55) and gender (male vs. female). We then evaluated the complications of certain clinicopathological features, serum adipocytokines, and genetic background in NASH. Obesity was observed in the younger subjects. Computed tomography (CT) scans revealed that the area of visceral fat was not significantly different between gender or age groups. Diabetes was an independent risk factor in liver cirrhosis in elderly females. Serum interleukin (IL)-6 level was lower and adiponectin was higher in females. In conclusion, gender differences and age were found to influence clinical features in NASH. Based on our observations, gender and age must be taken into consideration in order to establish an adequate treatment for NASH.

Journal

  • Kanzo

    Kanzo 55(4), 199-205, 2014

    The Japan Society of Hepatology

Codes

  • NII Article ID (NAID)
    130004495334
  • NII NACSIS-CAT ID (NCID)
    AN00047770
  • Text Lang
    JPN
  • ISSN
    0451-4203
  • NDL Article ID
    025409326
  • NDL Call No.
    Z19-130
  • Data Source
    NDL  J-STAGE 
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