書誌事項
- タイトル別名
-
- Treatment of Childhood Non-Hodgkin's Lymphoma with Multi-Drug Combination Protocol Including High Dose Methotrexate and Citrovorum Factor Rescue
- —Methotrexate大量療法を中心とした多剤併用化学療法—
抄録
Twenty six children with non-Hodgkin's lymphoma (NHL) were treated with multi-drug combination protocols including high-dose methotrexate (50∼200 mg/kg) (H-D-MTX) and citrovorum factor (CF) rescue.<br>The initial pilot study which was designed to evaluate the efficacy of H-D-MTX against the childhood NHL and was scheduled three administrations of weekly vincristine (VCR) and H-D-MTX (50, 100, 150 mg/kg) as the initial induction therapy, was investigated on seven patients (Stage I+II 3, III+IV 4). Out of seven patients who had sequential consolidation consisted of VCR, adriamysin (ADR), prednisolone (Pred), and H-D-MTX, followed the maintenance therapy with VCR, Pred, MTX (225 mg/m2), mercaptopurine (6MP), and pulse H-D-MTX every 14 weeks, four were achieved in complete remission (CR), and remained in no evidence of the disease for 9+-46+ months.<br>Five patients in 1981 to 1982 were treated with the protocol for high-risk ALL “CCLSG HR 811 A”, consisting of three-drug (VCR, Pred, cyclophosphamide (1,200 mg/m2) (CPM)) induction, the early consolidation with H-D-MTX and ADR, and the cyclic maintenance with H-D-MTX, VCR, 6MP, and Pred. Out of five patients, three were achieved in CR, and two of three CR patients were survived for 2.6+ and 29+ months without the evidence of the disease.<br>In the third study, 14 patients were treated with protocol “NHL 8201” consisted of four-drug (VCR, CPM, ADR, Pred) induction, consolidation with H-D-MTX, and cyclic maintenance with VCR, Pred, MTX, 6MP, CPM, ADR, and pulse H-D-MTX every 15 weeks. The CR induction rate was 78.6% and continuous CR rate estimated by Kaplan Mier method was 66.7% at 18-month.<br>The total CR induction was 69.2% (92% for Stage I+II and 46% for Stage III+IV), and three-year continuous CR rate was 74%. No CNS invasion was observed.<br>These data suggested that the early consolidation with H-D-MTX was highly effective to prevent the early systemic relapse as well as to prevent the meningeal involvement of childhood NHL.
収録刊行物
-
- 臨床血液
-
臨床血液 26 (5), 721-730, 1985
一般社団法人 日本血液学会
