Clinical Courses of 13 Cases of Long Survivors after Allogeneic Bone Marrow Transplantation

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  • TAHARA Tohru
    Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital First Department of Internal Medicine, Nagoya University School of Medicine
  • SAO Hiroshi
    Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital First Department of Internal Medicine, Nagoya University School of Medicine
  • YAMAUCHI Tatsuya
    Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital
  • MORISHIMA Yasuo
    First Department of Internal Medicine, Nagoya University School of Medicine
  • OHNO Ryuzo
    First Department of Internal Medicine, Nagoya University School of Medicine
  • IWAMURA Haruki
    Department of Pediatrics, Nagoya University School of Medicine
  • YOKOMAKU Shyozo
    Department of Internal Medicine, Aichiken-Shokuin Hospital
  • NAKAIDE Yasumitsu
    Department of Internal Medicine, National Nagoya Hospital
  • KODERA Yoshihisa
    Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital First Department of Internal Medicine, Nagoya University School of Medicine
  • YOSHIKAWA Satoshi
    Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital
  • Nagoya Bone Marrow Transplantation Group
    名古屋第一赤十字病院内科

Bibliographic Information

Other Title
  • 同種骨髄移植後の長期（2年以上）生存例13例の検討—臨床経過について
  • 同種骨髄移植後の長期(2年以上)生存例13例の検討--臨床経過について
  • ドウシュ コツズイ イショクゴ ノ チョウキ 2ネン イジョウ セイゾンレイ

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Abstract

Clinical courses of 13 patients who survived more than 2 years after allogeneic bone marrow transplantation (BMT) were analyzed. Ten patients with acute leukemia were conditioned with cyclophosphamide (CY) and total body irradiation (TBI). Eight of them received marrow graft at the first complete remission stage, and the other 2 received it at the second remission stage. Three patients with severe aplastic anemia were conditioned with CY alone. All except one who was given cyclosporin-A (CsA) were given MTX for prophylaxis of GVHD. Acute GVHD developed in 9 patients, but only 2 patients had severe GVHD (grade II or higher). Chronic GVHD which involved chiefly skin, liver and oral mucosa, developed in 11 patients. Four patients had interstitial pneumonia (IP), but all recovered. Most of patients had viral and/or bacterial infections during one year after BMT, but raly developed such infections after 2 years posttransplant. Serum IgM levels were depressed for 1 year and IgA levels for 2 years posttransplant.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 28 (2), 220-227, 1987

    The Japanese Society of Hematology

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